Minimal Models for Glucose and Insulin Kinetics
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چکیده
منابع مشابه
A minimal model of insulin secretion and kinetics to assess hepatic insulin extraction.
The liver is the principal site of insulin degradation, and assessing its ability to extract insulin is important to understand several pathological states. Noninvasive quantification of hepatic extraction (HE) in an individual requires comparing the profiles of insulin secretion (ISR) and posthepatic insulin delivery rate (IDR). To do this, we propose here the combined use of the classical C-p...
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In this paper, based on a fractional order Bergman minimal model, a robust strategy for regulationof blood glucose in type 1 diabetic patients is presented. Glucose/insulin concentration in the patientbody is controlled through the injection under the patients skin by the pump. Many various con-trollers for this system have been proposed in the literature. However, most of the...
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متن کاملModeling glucose and free fatty acid kinetics during insulin-modified intravenous glucose tolerance test in healthy humans: role of counterregulatory response.
Insulin administration during insulin-modified intravenous glucose tolerance test (IM-IVGTT) can induce transient hypoglycemia in healthy insulin-sensitive subjects. This triggers counterregulatory reflex (CRR) responses, which influence the kinetics of glucose and nonesterified fatty acids (NEFA), and undermines the accuracy of mathematical modeling methods that do not explicitly account for C...
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تاریخ انتشار 2004